High Osteocalcin Microcrystalline Hydroxyapatite For Calcium Supplement

摘要

An improved manufacturing process produces microcrystalline hydroxyapatrte with sustained gradual calcium release that avoids spiking in blood calcium levels. Although the improved material did not cause significant elevation of blood calcium, it was just as effective in promoting bone mineralization as conventional calcium supplements. In addition, the material has much higher levels of bone growth factors as compared to prior hydroxyapatite products.

主权项

1. A method for producing a high osteocalcin microcrystalline hydroxyapatite preparation without using organic solvents to remove fat comprising the steps of:
selecting bovine leg bone diaphysis; reducing the bovine leg bone to a predetermined particle size; digesting the reduced bovine leg bone with a protease under temperature controlled conditions, thereby removing fat; drying the digested bovine leg bone; and milling the digested leg bone to produce high osteocalcin microcrystalline hydroxyapatite with a predetermined particle size distribution, wherein the high osteocalcin microcrystalline hydroxyapatite does not cause elevation of ionized blood calcium levels when administered as a dietary supplement.