| 主权项 |
1. A compound of formula I,in which
I1, I2, I3, I4, I5, each, independently of one another, are N or CR′, T is phenyl or naphthyl, each of which is unsubstituted or mono-, di- tri- or tetrasubstituted by R, or a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono-, di- or trisubstituted by R, ═S, ═NR′ and/or ═O, R1 is linear or branched alkyl having 1-10 C atoms which is unsubstituted or mono-, di- or trisubstituted by ═S, ═NR, ═O, T, Hal, OH, NH2, SO2CH3, SO2NH2, CN, CONH2, NHCOCH3, NHCONH2 and in which one, two or three CH2 groups may each be replaced, independently of one another, by O, S, SO, SO2, NH, NCH3, —OCO—, —NHCONH—, —NHCO—, —NRSO2R′—, —COO—, —CONH—, —NCH3CO—, —CONCH3—, —C≡C— groups or —CH═CH— groups, and/or, in addition, 1-20 H atoms may each be replaced by F or Cl, or cyclic alkyl having 3-7 C atoms which is unsubstituted or mono-, di- or trisubstituted by ═S, ═NR, ═O, T, OH, NH2, SO2CH3, SO2NH2, CN, CONH2, NHCOCH3 and/or NHCONH2 and in which one, two or three CH2 groups may each be replaced, independently of one another, by O, S, SO, SO2, NH, NCH3, —OCO—, —NHCONH—, —NHCO—, —NRSO2R′—, —COO—, —CONH—, —NCH3CO—, —CONCH3—, —C≡C— or —CH═CH— groups and/or, in addition, 1-11 H atoms may each be replaced by F or Cl, A1 is 0 to 4 amino acid radicals which are bonded to one another in a peptide-like manner —CO—, —OCO—, —NRCO—, —SO2— or —NRSO2—, A2 is 0 to 4 amino acid radicals which are bonded to one another in a peptide-like manner, L1 is a single bond or —CRR′—, L2 is a single bond, —CRR′—, —NR—, —NRCR′R— or —NRCRR′CRR′—, X, Y are each, independently, H, T, linear or branched alkyl having 1-10 C atoms which is unsubstituted or mono-, di- or trisubstituted by ═S, ═NR, ═O, R, T, OR, NRR′, SOR, SO2R, SO2NRR′, CN, COOR, CONRR′, NRCOR′, NRCONR′R″, NRSO2R′ and/or NRCOR′ and in which one, two or three CH2 groups may each be replaced, independently of one another, by O, S, SO, SO2, NR, —OCO—, —NRCONR′—, —NRCO—, —NRSO2R′—, —COO—, —CONR—, —C≡C— or —CH═CH— groups and/or, in addition, 1-20 H atoms may each be replaced by F or Cl, or linear or branched cyclic alkyl having 3-7 C atoms which is unsubstituted or mono-, di- or trisubstituted by ═S, ═NR, ═O, R, T, OR, NRR′, SOR, SO2R, SO2NRR′, CN, COOR, CONRR′, NRCOR′, NRCONR′R″, NRSO2R′ and/or NRCOR′ and in which one, two or three CH2 groups may each be replaced, independently of one another, by O, S, SO, SO2, NR, —OCO—, —NRCONR′—,—NRCO—, —NRSO2R′—, —COO—, —CONR—, —C≡C— or —CH═CH— groups and/or, in addition, 1-11 H atoms may each be replaced by F or Cl, R, R′, independently of one another, are H, linear or branched alkyl having 1-10 C atoms which is unsubstituted or mono-, di- or trisubstituted by ═S, ═NR, ═O, Hal, OH, NH2, SO2CH3, SO2NH2, CN, CONH2, NHCOCH3, and/or NHCONH2 and in which one, two or three CH2 groups may each be replaced, independently of one another, by O, S, SO, SO2, NH, NCH3, —OCO—, —NHCONH—, —NHCO—, —NRSO2R′—, —COO—, —CONH—, —NCH3CO—, —CONCH3—, —C≡C— or —CH═CH— groups and/or, in addition, 1-20 H atoms may each be replaced by F or Cl, or cyclic alkyl having 3-7 C atoms which is unsubstituted or mono-, di- or trisubstituted by ═S, ═NR, ═O, OH, NH2, SO2CH3, SO2NH2, CN, CONH2, NHCOCH3, and/or NHCONH2 and in which one, two or three CH2 groups may each be replaced, independently of one another, by O, S, SO, SO2, NH, NCH3, —OCO—, —NHCONH—, —NHCO—, —NRSO2R′—, —COO—, —CONH—, —NCH3CO—, —CONCH3— or —CH═CH— groups and/or, in addition, 1-11 H atoms may each be replaced by F or Cl, m is 0-4, n is 0-2, and Hal is F, Cl, Br or I,or a physiologically acceptable salt, derivative, solvate, prodrug or stereoisomer thereof, including mixtures thereof in all ratios. |
