| 发明名称 |
Compounds of Chemically Modified Oligonucleotides and Methods of Use Thereof |
| 摘要 |
The present disclosure relates to isolated compounds including a nucleic acid sequence capable of hybridizing to an RNA sequence 10 to 270 nucleobases downstream of the transcription start site of a mammalian microRNA-379 transcript; method of treating diabetic nephropathy in a subject with the compounds; and method of inhibiting expression of a mammalian microRNA-379 megacluster with the compounds. |
| 申请公布号 |
US2016348105(A1) |
申请公布日期 |
2016.12.01 |
| 申请号 |
US201615163816 |
申请日期 |
2016.05.25 |
| 申请人 |
City of Hope |
发明人 |
Natarajan Rama;Kato Mitsuo |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated compound comprising a nucleic acid sequence capable of hybridizing to an RNA sequence 10 to 270 nucleobases downstream of the transcription start site of a mammalian microRNA-379 transcript comprising nucleic acid sequence corresponding to a transcript of the consensus sequence provided in SEQ ID NO: 51, wherein said nucleic acid sequence comprises a nucleobase analog or internucleotide linkage. |
| 地址 |
Duarte CA US |
