CRF BINDING PROTEIN

摘要

Corticotropin Releasing Factor-binding protein (CRF-BP) is produced recombinantly and is useful for modulating the biological activity of CRF. CRF-BP or fragments thereof and/or antibodies to the proteins are employed in diagnostic assays to determine the levels of CRF, CRF-BP and the ratio of CRF/CRF-BP in a vascular fluid sample. Following such an assay, CRF-BP can be effectively employed to treat pregnancy-related pathological disorders by lowering the ratio of CRF/CRF-BP to within a normal range for pregnancy. The anti-CRF-BP antibodies are also useful to purify the CRF-BP and to modulate the biological effect of CRF-BPs.