| 摘要 |
Disclosed is an isolated antigen binding protein that induces FGF21-mediated signaling, wherein the antigen binding protein comprises: (a) a light chain CDR1 comprising an amino acid sequence at least SEQ ID NO: 166 or a light chain CDR1 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 166 (GGNNIGSESVH); (b) a light chain CDR2 comprising SEQ ID NO: 176 or a light chain CDR2 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 176 (DDSDRPS); (c) a light chain CDR3 comprising SEQ ID NO: 188 or a light chain CDR3 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 188 (QVWDGNSDHVV); (d) a heavy chain CDR1 comprising SEQ ID NO: 122 or a heavy chain CDR1 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 122 (NARMGVS); (e) a heavy chain CDR2 comprising SEQ ID NO: 133 or a heavy chain CDR2 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 133 (HIFSNDEKSYSTSLKS); and (f) a heavy chain CDR3 comprising SEQ ID NO: 148 or a heavy chain CDR3 sequence that differs by no more than a total of three amino acid additions, substitutions, and/or deletions from SEQ ID NO: 148 (SVVTGGYYYDGMDV). |
