Steroid compounds with a c17-alkyl side chain and an aromatic a-ring for use in therapy

摘要

Formula (I) in which: R¹ and R², which may be the same or different, each represents a lower alkyl, alkenyl or alkynyl group; R³ represents a methyl group having alpha- or beta-configuration; R⁴ represents a hydrogen atom or an etherifying or esterifying group; R⁵ represents a hydrogen atom, a hydroxyl group or a lower alkoxy group; X represents a group OR⁴, or a group NR⁶R⁷ wherein R⁶ represents a hydrogen atom, an aliphatic or araliphatic group, or an acyl group comprising an aliphatic, araliphatic or aryl group linked to the nitrogen atom by way of a carbonyl group; and R⁷ is a hydrogen atom or a lower alkyl group; Y represents a lower alkylene, alkenylene or alkynylene group optionally substituted by a hydroxyl, etherified hydroxyl or esterified hydroxyl group; exhibit potent effects on modulation of cell growth and differentiation, while having low calcaemic activity.