摘要 |
<p>Compounds possessing 5HT7 activity of formula (I) or a pharmaceutically acceptable salt thereof are disclosed (Formula I), in which X is a 5 or 6 membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitroxygen and sulfur; R2 is alogen, C1-6alkyl, haloC1-6alkyl, hydroxy, C1-6alkoxy or C1-6alkylthio; R3 is hydrogen, C1-6alkyl, hydroxy or oxo; m is 0, 1 or 2; p is 0, 1 or 2; n is 1 or 2; R4 and R5 are both hydrogen, or R4 and R5 combine together to form a further group: -(CH2)q- where q is 2 or 3; D is a single bond, C1-4alkylene, C=O or oxygen; Z is either a group (a) (Formula II), in which R1 is halogen, C1-6alkyl, cyano, haloC1-6cycloalkyl, C1-6alkoxy, hadroxy, amino, mono- or di-C1-6alkylamino, acylamino, nitro, carboxy, C1-6alkoxycarbonyl, C1-6alkylthio, C1-6alkylsulfinyl, C1-6alkylsulfonyl, sulfamoyl, mono- and di-C1-6alkylsulfamoyl, carbamoyl, mono- or di-C1-6alkylcarbamoyl, C1-6alkylsulfonamido, aryl, arylC1-6alkyl, arylC1-6alkoxy, aryloxy or arylthio, and y is 0, 1, 2 or 3; or a group (b) (formula III), in which P is a 5 membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur; R8 is hydrogen, C1-6alkyl, hydroxy or oxo; R6 and R7 form the residue of a phenyl ring or a 6 membered heteroaryl ring comprising from one to three heteroatoms selected from nitrogen, oxygen and sulfur and optionally substituted with one or two substitutents which may be the same or different and selected from the group consisting of halogen, C1-6alkyl, cyano, haloC1-6alkyl, C3-7cycloalkyl, C1-6alkoxy, hydroxy, amino, mono- or di-C1-6alkylamino, acylamino, nitro, carboxy, C1-6alkoxycarbonyl, C1-6alkylthio, C1-6alkylsulfinyl, C1-6alkylsulfonyl, sulfamoyl, mono- and di-C1-6alkylsufamoyl, carbamoyl, mono- and di-C1-6alkylcarbamoyl, C1-6alkylsulfonamido, arylsulfonamido, aryl, arylC1-6alkyl, arylC1-6alkoxy, aryloxy and arylthio. Also disclosed are processes for preparation of the compounds, and uses in the treatment of CNS and other disorders.</p> |