Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide

摘要

Disclosed herein are methods for counteracting age-related decrease in gene expression or treating age-related diseases, for example cancers and autoimmune diseases, caused by decreased expression levels of a gene associated with the apoptosis pathway, using a nitroxide. Further disclosed are methods for treating a human subject in need of an increased expression level of a gene associated with the apoptosis pathway using a nitroxide.

主权项

1. A method for treating an individual having cancer, comprising:
identifying an individual having a cancer whose expression level of Unc5b is downregulated; and administering to the individual an effective amount of a nitroxide antioxidant, wherein the nitroxide antioxidant is 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl, whereby the expression level of Unc5b is increased.