SUBSTITUTED AZEPINO[4,3-B]INDOLES, PHARMACOLOGICAL COMPOSITION AND A METHOD FOR THE PRODUCTION AND USE THEREOF

摘要

The invention relates to synthesising novel chemical agents, to searching novel physiologically active substances, leading compounds, "molecular tools" and drug candidates produced by screening combinatorial and focused libraries of compounds, to a pharmaceutical composition and to methods for the production and use thereof. The invention claims hydrated substituted azepino[4,3-b]indoles of general formula 1, the racemates, optical and geometrical isomers and the pharmaceutically acceptable salts and/or hydrates thereof, wherein a dotted line with an unbroken line associated therewith (__----) is a single or double bond; R¹ and R² independently of one another represent aminogroup substituents selected from hydrogen; from possibly substituted C₁-C₈ alkyl, possibly substituted by aryl, 5-6-membered azaheterocyclyl; from C₁-C₈ alkoxycarbonyl; from possibly substituted phenyl; possibly carbonylamino or tiocarbonylamino substituted; from substituted acyl, C₁-C₈ alkylsulphonyl, possibly substituted arylsulphonyl; wherein substituents in said R₁ and R₂ are independently selected from C₁-C₈ alkyl, halogen atoms, nitro, carboxy and alkoxy aryl; R ^_i