| 摘要 |
There is described a process for the preparation of a stereospecific form of flurbiprofen, or a pharmaceutically acceptable salt thereof, which comprises subjecting a flurbiprofen ester, comprising a mixture (R)-(-)-flurbiprofen and (S)-(+)-flurbiprofen, to the action of an biocatalyst capable of stereo selective de-esterification of the ester; provided that the biocatalyst is not Aspergillus oryzae; Bacillus cereus C71; Candida Antarctica lipase B (Novozym ® 435); Candida cylindracea; Candida rugosa lipase; Carica papaya lipase; Pseudomonas sp. KCTC 10122BP and Serratia marcescens ES-2. |
