Zeolites for delivery of nitric oxide

摘要

There is described zeolites containing releasably adsorbed nitric oxide, methods of preparing the zeolites, methods of releasing the nitric oxide into a solution or into air and uses of the zeolites in therapy.

主权项

1. A method of releasing nitric oxide (NO) at body or room temperature from a zeolites comprising extra-framework cations, the method comprising the steps of:
(i) providing a partially or fully dehydrated aluminosilicate zeolites comprising extra-framwork cations selected from the group consisting of Fe, Cu, Ru, Rh, Co, Ni, Zn, and Ag, the extra-framework cations being effective to chemically bind nitric oxide and having nitric oxide bound thereto, (ii) contacting the zeolites from (i) with moisture at body or room temperature, whereby nitric oxide is displaced from the zeolites and released, wherein the providing step comprises administering the zeolites to an animal subject either inside the animal subject or topically, and the contacting and release of nitric oxide occurs either inside the animal body or topically, respectively.