Use of pulmonary surfactants in lung transplantation and methods thereof

摘要

The present invention concerns a method of treating an advanced lung disease in a patient in need thereof by lung transplantation.

主权项

1. A method of treating an advanced lung disease selected from the group consisting of advanced chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), emphysema due to alpha-1 antitrypsin deficiency, and idiopathic pulmonary arterial hypertension (IPAH) in a patient in need thereof by lung transplantation, said method comprising:
(i) withdrawing a lung with trachea to be implanted from a donor and dissecting it on a backtable; (ii) administering a therapeutically effective amount of an aqueous suspension of pulmonary surfactant poractant alfa having a concentration of 80 mg/ml based on the total volume of said aqueous suspension directly into the trachea on said back table after withdrawal of said lung; (iii) preserving said lung until implantation; and (iv) transplanting said lung into said patient, wherein said preserving said lung (iii) is carried out by applying a hypothermic (cold) static lung preservation technique.