发明名称 |
RESISTANT MUTANT 90 kDA HEAT SHOCK PROTEIN |
摘要 |
An object to be solved by the present invention is to identify patients resistant to known HSP90 inhibitors, and to provide a novel therapeutic agent for treating the patients who have become resistant to known HSP90 inhibitors.;As a means for solving the above problems, the present invention provides identification of the patients based on a protein, which is an HSP90 family protein having a mutation in the site corresponding to F138 of HSP90α class A consisting of the amino acid sequence of SEQ ID NO: 1, and use of a substance that inhibits the protein as an active ingredient of a therapeutic agent. |
申请公布号 |
US2016311871(A1) |
申请公布日期 |
2016.10.27 |
申请号 |
US201415026413 |
申请日期 |
2014.10.02 |
申请人 |
TAIHO PHARMACEUTICAL CO., LTD. |
发明人 |
Yoshimura Chihoko;Kodama Yasuo;Ohkubo Shuichi |
分类号 |
C07K14/47;G01N33/68;A61K47/48;C07K16/18;A61K31/437 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
1. An HSP90 family protein having a mutation in the site corresponding to F138 of HSP90α class A consisting of the amino acid sequence of SEQ ID NO: 1; or a part of the protein having the mutation. |
地址 |
Tokyo JP |