| 发明名称 |
ADJUVANT FOR MUCOSAL VACCINE |
| 摘要 |
An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response on the mucosa. According to the present invention, an adjuvant for a mucosal vaccine comprising a protein complex composed of hemagglutinin (HA) subcomponents HA1, HA2, and HA3 of botulinum toxin is provided. |
| 申请公布号 |
US2016324960(A1) |
申请公布日期 |
2016.11.10 |
| 申请号 |
US201615223566 |
申请日期 |
2016.07.29 |
| 申请人 |
DAIICHI SANKYO COMPANY, LIMITED ;OSAKA UNIVERSITY |
发明人 |
Fujinaga Yukako;Matsumura Takuhiro;Yutani Masahiro;Jonai Nao |
| 分类号 |
A61K39/39;A61K39/145;C12N7/00;C07K14/33 |
主分类号 |
A61K39/39 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of enhancing systemic and mucosal immune responses against a vaccine antigen in a subject, comprising administering to the subject an adjuvant comprising a protein complex composed of hemagglutinin (HA) subcomponents HA1, HA2, and HA3 of botulinum toxin in combination with the vaccine antigen, wherein the protein complex is composed of (i) a protein consisting of the amino acid sequence as shown in SEQ ID NO: 1, (ii)) a protein consisting of the amino acid sequence as shown in SEQ ID NO: 2, and (iii) a protein consisting of the amino acid sequence as shown in SEQ ID NO: 3. |
| 地址 |
Tokyo JP |
