| 发明名称 |
TEMPERATURE STABLE VACCINE FORMULATIONS |
| 摘要 |
Vaccine antigen formulations that are stable after undergoing freeze and thaw conditions and methods of preparing the formulations are provided. Methods of using the formulations to prepare vaccine are also provided. Vaccines comprising the formulations are useful, for example, to protect against, inhibit or alleviate a disease or infection, such as related to anthrax infection. |
| 申请公布号 |
US2016324957(A1) |
申请公布日期 |
2016.11.10 |
| 申请号 |
US201415108244 |
申请日期 |
2014.12.23 |
| 申请人 |
EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. |
发明人 |
LOOK Jee;RUIZ Christian Fernando;MILES Aaron Paul;WELCH Richard William |
| 分类号 |
A61K39/39;A61K9/19;C12N7/00;A61K39/07;A61K39/145 |
主分类号 |
A61K39/39 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing a stable lyophilized vaccine, the method comprising
(a) exchanging at least part of a liquid component of a first composition comprising at least one antigen adsorbed to an aluminum adjuvant with a second liquid component comprising a non-reducing sugar to create a second composition that comprises at least 20% (w/v) non-reducing sugar; and (b) lyophilizing the second composition. |
| 地址 |
Gaithersburg MD US |
