发明名称 |
NOVEL AEROSOL FORMULATIONS OF ONDANSETRON AND USES THEREOF |
摘要 |
Aerosol formulations of ondansetron useful for pulmonary delivery are provided. The formulations are useful in the reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONV) using the inhalation formulations. |
申请公布号 |
US2016324775(A1) |
申请公布日期 |
2016.11.10 |
申请号 |
US201615154431 |
申请日期 |
2016.05.13 |
申请人 |
LI Xiaodong;LU George;LU Biao |
发明人 |
LI Xiaodong;LU George;LU Biao |
分类号 |
A61K9/00;A61K9/16;A61K31/4178 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
1: A formulation, comprising:
ondansetron having a mass median aerodynamic diameter of between 0.05 and 20 microns; and optionally at least one selected from the group consisting of a pharmaceutically acceptable excipient and a propellant, wherein the excipient is selected from the group consisting of a carbohydrate, an amino acid, a polypeptide, a lipid, a salt, a polyalcohol, an oleate, a stearate, a myristate, an alkylether, an alkyl arylether, and a sorbate. |
地址 |
Sunnyvale CA US |