The present application provides a method and system for eliminating crosstalk, the method comprising: performing a frequency division processing on an original audio signal of a sound channel to obtain a sub-band signal; performing a time-delay and gain processing on the sub-band signal according to a predetermined time-delay value and gain value corresponding to the sub-band signal; generating a crosstalk elimination signal according to the sub-band signal having undergone the time-delay and gain processing; and synthesizing the crosstalk elimination signal with an original audio signal of another sound channel to obtain a play signal. The present application can eliminate the crosstalk effectively.