Benzodioxole derivative and preparation method and use thereof

摘要

Provided in the present invention are novel benzodioxole derivatives and preparation methods thereof. These compounds represented by formula (I) or pharmaceutically acceptable salts thereof have acetylcholinesterase inhibitory activity, so can be used in the treatment or prevention of Alzheimer's disease. The definitions of R1, R2 and A of formula (I) can be seen in the description.;

主权项

1. A compound represented by formula (I) or a pharmaceutically acceptable salt, wherein: R1 and R2 together is ═O; or, R1 and R2 together with the carbon atom connecting them can form a 3-membered carbon ring; A is selected from the group consisting of phenyl, R3-substituted phenyl, pyridinyl, R4-substituted pyridinyl, pyrimidinyl, R5-substituted pyrimidinyl, pyrrolyl, R6-substituted pyrrolyl, pyridazinyl, R7-substituted pyridazinyl, pyrazolyl, and R8-substituted pyrazolyl; R3 is 1 to 5 substituents independently selected from the group consisting of halogen, (C1-C3) alkyl, (C2-C3) alkenyl, (C3-C4) cycloalkyl, (C1-C3) alkoxy, trifluoromethyl and cyano; R4 is 1 to 4 substituents independently selected from the group consisting of halogen, (C1-C3) alkyl, (C2-C3) alkenyl, (C3-C4) cycloalkyl, (C1-C3) alkoxy, trifluoromethyl and cyano; R5 is 1 to 3 substituents independently selected from the group consisting of halogen, (C1-C3) alkyl, (C2-C3) alkenyl, (C3-C4) cycloalkyl, (C1-C3) alkoxy, trifluoromethyl and cyano; R6 is 1 to 4 substituents independently selected from the group consisting of (C1-C3) alkyl, (C2-C3) alkenyl and (C3-C4) cycloalkyl; R7 is 1 to 3 substituents independently selected from the group consisting of halogen, (C1-C3) alkyl, (C2-C3) alkenyl, (C3-C4) cycloalkyl, (C1-C3) alkoxy, trifluoromethyl and cyano; R8 is 1 to 3 substituents independently selected from the group consisting of (C1-C3) alkyl, (C2-C3) alkenyl and (C3-C4) cycloalkyl.