发明名称 |
CARDIAC REENTRY MODEL CHIP AND APPARATUS AND METHOD FOR EVALUATING DRUG USING THE CARDIAC REENTRY MODEL CHIP |
摘要 |
A chip has been developed that can accurately measure cell potential and cell morphology on a single cell basis. The chip also constitutes a cardiac model that comprises a closed loop whereupon cardiomyocytes and fibroblasts are suitably dispersed and arranged, and that can evaluate the effects of a drug thereon. An in vitro cardiac reentry model chip is fabricated by constructing a closed loop comprising cardiomyocytes and fibroblasts arrayed on transparent electrodes formed on a transparent substrate by susing a constitution where single cells are enclosed in a specific spatial configuration. A pulse wave of a random cardiomyocyte or a specific cardiomyocyte is propagated on both sides of the loop, and the pulsation status of the cells in the loop is detected electrically. A drug is applied to this cardiac reentry model chip, and the benefit or toxicity of the drug to cardiomyocytes is evaluated by measuring the cell potentials of individual cells.
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申请公布号 |
EP2157165(A1) |
申请公布日期 |
2010.02.24 |
申请号 |
EP20080765260 |
申请日期 |
2008.06.06 |
申请人 |
NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL ANDDENTAL UNIVERSITY;MITSUBISHI CHEMICAL MEDIENCE CORPORATION |
发明人 |
YASUDA, KENJI;SUGIYAMA, ATSUSHI;ANDO, KENTARO;NOMURA, FUMIMASA;TERAZONO, HIDEYUKI;KANEKO, TOMOYUKI;FUKUSHIMA, MAMORU |
分类号 |
G01N33/50;G01N33/487;G01N33/543 |
主分类号 |
G01N33/50 |
代理机构 |
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