High-Speed Molecular Diagnostics

摘要

A system for high-speed molecular diagnostics includes a self-resetting continuous-time integrator configured to integrate an input current on one of a plurality of integration capacitors to generate an integrated voltage. A self-resetting continuous-time differentiator is configured to differentiate the integrated voltage on one of a plurality of differentiating capacitors to generate an output voltage proportional to the input current. A fixed-threshold window comparator is configured to reset one of the plurality of integration capacitors, reset one of the plurality of differentiating capacitors, open a second one of the plurality of integration capacitors and open a second one of the plurality of differentiating capacitors in response to the integrated voltage exceeding a voltage range.

主权项

1. A method for high-speed molecular diagnostics comprising:
integrating an input current to generate an integrated voltage proportional to a first integrated charge stored thereby on a first resettable capacitor of an integrator; switching between a first one and a second one of a plurality of clock phases in response to the integrated voltage exceeding a voltage range; shorting the first resettable capacitor with a first switch controlled by the first one of the plurality of clock phases to equalize the first integrated charge stored on the first resettable capacitor; and opening a second resettable capacitor with a second switch controlled by a second one of the plurality of clock phases, wherein the second resettable capacitor is connected in series with the first resettable capacitor in a negative feedback loop of the integrator.