发明名称 |
METHODS AND MATERIALS FOR USING TRANSGENIC NON-HUMAN ANIMALS EXPRESSING SODIUM IODIDE SYMPORTER POLYPEPTIDES TO MONITOR PATHOLOGICAL PROCESSES, DISEASE PROGRESSION, OR THERAPEUTIC RESPONSES OVER TIME |
摘要 |
This document provides methods and materials for using live transgenic non-human animals (e.g., non-human mammals) to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time. For example, methods and materials for using live transgenic non-human animals (e.g., non-human mammals) having somatic and germline cells that include nucleic acid (e.g., a transgene) having a promoter sequence operably linked to a nucleic acid sequence encoding a NIS polypeptide to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time are provided. |
申请公布号 |
WO2016168683(A3) |
申请公布日期 |
2016.11.17 |
申请号 |
WO2016US27876 |
申请日期 |
2016.04.15 |
申请人 |
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
PENG, Kah-Whye;RUSSELL, Stephen James;LECH, Patrycja;SUKSANPAISAN, Lukkana |
分类号 |
A61K35/02;C12N15/85 |
主分类号 |
A61K35/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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