SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE

摘要

Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y<SUP>1</SUP>, Y<SUP>2</SUP>, Y<SUP>3</SUP>, Y<SUP>4</SUP> represent N or C-, whereby at least two of the groups Y<SUP>1</SUP> to Y<SUP>4</SUP> denote a carbon atom, R<SUP>1</SUP> represents chloro or bromo, R<SUP>2</SUP> to R7 represent e.g. hydrogen, methyl or ethyl; and R<SUP>10</SUP> and R<SUP>11</SUP> independent ly represent e.g. hydrogen or C<SUB>1</SUB>-C<SUB>6</SUB>alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.