发明名称 |
METHOD FOR IDENTIFYING CANCER DRUG CANDIDATES IN DROSOPHILA |
摘要 |
A process for preparing information that identifies a compound as capable of perturbing the epithelium in a D. melanogaster comprising the steps of: i) obtaining a D. melanogaster which is genetically unmodified except that the D. melanogaster optionally comprises at least one nucleotide sequence encoding a reporter polypeptide operably linked to a promoter of an endogenous protein; ii) contacting the D. melanogaster with the compound; and iii) determining whether there is a difference between the epithelium of the D. melanogaster of ii) and the epithelium of a corresponding D. melanogaster not contacted with the compound, wherein the presence of a difference between the epithelium of the D. melanogaster contacted with the compound and the epithelium of a corresponding D. melanogaster not contacted with the compound identifies the compound as a compound that is capable of perturbing the epithelium in a D. melanogaster. |
申请公布号 |
CA2796520(A1) |
申请公布日期 |
2013.05.18 |
申请号 |
CA20122796520 |
申请日期 |
2012.11.16 |
申请人 |
THELIAL TECHNOLOGIES S.A. |
发明人 |
MARTINHO, RUI GONCALO VIEGAS RUSSO DA CONCEICAO;MARQUES, VIRGINIA MYLENA DE OLIVEIRA;HAMPSON, RICHARD JOHN |
分类号 |
C12Q1/68;C12Q1/00;C40B30/06;G01N33/48;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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