发明名称 |
Modified binding proteins inhibiting the VEGF-A receptor interaction |
摘要 |
MODIFIED BINDING PROTEINS INHIBITING THE VEGF-A RECEPTOR INTERACTION The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration. |
申请公布号 |
AU2014243418(B2) |
申请公布日期 |
2016.09.22 |
申请号 |
AU20140243418 |
申请日期 |
2014.10.09 |
申请人 |
Molecular Partners AG |
发明人 |
Binz, Hans Kaspar;Forrer, Patrik;Stumpp, Michael Tobias |
分类号 |
A61K47/48;A61P27/02;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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