AGENTS AND METHODS FOR INHIBITING HUMAN PLURIPOTENT STEM CELL GROWTH

摘要

The present invention relates to compositions and methods for inhibiting or suppressing undifferentiated or pluripotent stem cell growth and proliferation in a differentiated or differentiating cell population or culture.

主权项

1. An in vitro composition comprising a combination of:
a) at least one human pluripotent stem cell wherein the pluripotent cell has the ability to differentiate into cells of all three germ layers; and b) an effective amount of a pluripotent stem cell-selective inhibitor or cytotoxic agent selected from the group consisting of caffeic acid, ivermectin, chelerythrine chloride or a mixture thereof, wherein the effective amount inhibits pluripotent cell growth in the composition as compared to pluripotent cell growth in a composition that does not comprise the effective amount of the inhibitor or cytotoxic agent.