| 摘要 |
[Problem] To provide an external skin preparation solid substrate exhibiting high breaking strength and usable as a stick-shaped substrate or the like. [Solution] An external skin preparation solid substrate containing: a lipid-peptide-type compound comprising one or more types selected from among a compound represented by formula (1), a compound similar thereto, or a pharmaceutically usable salt thereof; a surfactant; water; and 1,3-alkanediol. (In the formula, R1 represents a C9-23 aliphatic group, R2 represents a hydrogen atom or a C1-4 alkyl group that may have a C1 or C2 branched chain, R3 represents a -(CH2)n-X group, n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH2 group, or a five-membered or six-membered ring group which may have 1 to 3 nitrogen atoms or a condensed heterocyclic group configured from the five-membered ring and the six-membered ring.) |
