| 摘要 |
PROBLEM TO BE SOLVED: To obtain a newly prepared fentanyl-containing percutaneously absorbable administration matrix type patch including fentanyl or a salt thereof, having easiness for administration and control of adjustment of dosage and also, short percutaneous absorption delay time (time for cutaneous permeation rate to reach its steady state) (within 4 h) and capable of stably maintaining its effects by keeping stable blood concentrations. SOLUTION: This fentanyl-containing percutaneous absorbable administration matrix type patch is obtained by including fentanyl or a salt thereof in a tacky base consisting of a hydrophobic tack agent, a hydrophilic tack agent and N-methyl-2-pyrrolidone. This patch exhibits the percutaneously absorbable delay time for the drug of within 4 h. In the patch, fentanyl or a salt thereof is compounded at 1-10 wt.%; the hydrophobic tack agent at 10-50 wt.%; the hydrophilic tack agent at 5-30 wt.%; and N-methyl-2-pyrrolidone at 2-10 wt.%.
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