Therapeutic piperazine derivatives useful for treating pain

摘要

Disclosed are cyanoiminopiperazine compounds of formula (I) wherein A, R1, R2, R3 and R6 are disclosed in the specification. The disclosed compounds are useful in the treatment of pain, urinary incontinence, ulcers, inflammatory bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression.