发明名称 |
VIRAL VECTORS EXPRESSING FUSION OF VIRAL LARGE ENVELOPE PROTEIN AND PROTEIN OF INTEREST |
摘要 |
The present invention provides a virus-like particle (VLP) comprising i) a polypeptide comprising a polypeptide of interest (POI) and at least a particle-associating portion of a large envelope (L) polypeptide of an avian hepadnavirus or a functional derivative or homolog thereof, and ii) a small envelope (S) polypeptide of an avian hepadnavirus or a functional derivative or homolog thereof. By introducing one or more POIs into the L polypeptide, the POI is translocated along with L into a particle structure made up primarily of S polypeptide. The present invention furthermore provides methods for producing a recombinant virus-like particle. |
申请公布号 |
EP1620558(A4) |
申请公布日期 |
2007.05.02 |
申请号 |
EP20040727789 |
申请日期 |
2004.04.16 |
申请人 |
HEPGENICS PTY LTD |
发明人 |
ANDERSON, DAVID, ANDREW;GRGACIC, ELIZABETH, VERA, LUDMILLA |
分类号 |
C12N7/04;C12N5/10;C12N7/01;C12N15/62;C12N15/86 |
主分类号 |
C12N7/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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