发明名称 |
New strategies for treating melanoma |
摘要 |
The present invention relates to a p53-activating agent capable of transferring wild-type tumor protein p53 (p53) from an inactive conformation into an active conformation capable of inducing apoptosis, for use in the treatment of melanoma, wherein said p53-activating agent is administered simultaneously or sequentially with a BRAF-inhibiting agent capable of inhibiting activity of serine/threonine-protein kinase B-Raf (BRAF) comprising an activating mutation. |
申请公布号 |
AU2015239108(A1) |
申请公布日期 |
2016.10.20 |
申请号 |
AU20150239108 |
申请日期 |
2015.04.01 |
申请人 |
Universite Libre de Bruxelles;Institut Jules Bordet |
发明人 |
Ghanem, Ghanem;Journe, Fabrice;Krayem, Mohammad;Awada, Ahmad |
分类号 |
A61K31/437;A61K31/439;A61K31/44;A61K31/4427;A61K31/4439;A61K31/46;A61K31/496;A61K31/506;A61K31/517;A61K31/519;A61K31/52;A61K31/5377;A61K38/08;A61K45/06;A61P35/00;C12Q1/68;G01N33/50 |
主分类号 |
A61K31/437 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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