摘要 |
The present teachings relate to compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I and methods of inhibiting matrix metalloproteinases, in particular, MMP-12, that may be involved in pathological disorders found in mammals, including a human.
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申请人 |
WYETH;LI, WEI;LI, JIANCHANG;WU, YUCHUAN;WU, JUNJUN;HOTCHANDANI, RAJEEV;TAM, STEVE;MANSOUR, TAREK;SYPEK, JOSEPH P.;MCFADYEN, IAIN |
发明人 |
LI, WEI;LI, JIANCHANG;WU, YUCHUAN;WU, JUNJUN;HOTCHANDANI, RAJEEV;TAM, STEVE;MANSOUR, TAREK;SYPEK, JOSEPH P.;MCFADYEN, IAIN |