| 发明名称 |
MONOCLONAL ANTIBODY AND A METHOD THEREOF |
| 摘要 |
The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types. |
| 申请公布号 |
US2016168256(A1) |
申请公布日期 |
2016.06.16 |
| 申请号 |
US201514969461 |
申请日期 |
2015.12.15 |
| 申请人 |
CENTRO DE INMUNOLOGIA MOLECULAR ;BIOCON LIMITED |
发明人 |
MELARKODE RAMAKRISHNAN;NAIR PRADIP;RAJKUMAR SUNDARAJ DAVID;SASTRY KEDARNATH NANJUND;CHATTERJI MONALISA;ADHIKARY LAXMI;BALASUBRAMANIAN HEMA;CASIMIRO JOSE ENRIQUE MONTERO;VALLADARES JOSEFA LOMBARDERO;RODRIGUEZ ROLANDO PEREZ |
| 分类号 |
C07K16/28;A61K39/395;A61K45/06 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inhibiting naïve T cell proliferation, the method comprising administering a therapeutically effective amount of a monoclonal anti-CD6 antibody that binds to domain 1 (D1) of CD6 without interfering with ALCAM binding, wherein the monoclonal antibody comprises heavy and light chain variable regions comprising amino acid sequences as set forth in SEQ ID NOs: 1 and 2. |
| 地址 |
HAVANA CITY CU |
