发明名称 Clickable polyoxetane carrier for drug delivery
摘要 A polymer is provided, comprising a subunit having the formula:; wherein A, B, C, D, a, b, c, d, and p are defined herein. Compositions, methods of making, and methods of use are provided.
申请公布号 US9421276(B2) 申请公布日期 2016.08.23
申请号 US201314425316 申请日期 2013.09.03
申请人 VIRGINIA COMMONWEALTH UNIVERSITY 发明人 Yang Hu;Zolotarskaya Olga;Wynne Kenneth J.;Valerie Kristoffer
分类号 C08G63/91;A61K47/48;C08G65/18;C08G65/333;A61K31/4745;C08G65/32 主分类号 C08G63/91
代理机构 Neifeld IP Law, PC 代理人 Neifeld IP Law, PC
主权项 1. A polymer, comprising a subunit having the formula: wherein: A is independently hydrogen, C1-10 alkyl, C3-10 alkenyl, C3-10 alkynyl, C3-20 cycloalkyl, C5-20 cycloalkenyl, C5-25 aryl, —OR1, —COOR1, —C(O)R1, —C(O)-halogen, —SR1, —OSO2R1, —CONR1R2, —NR1R2, —N3, or halogen; B is independently C1-10 alkylene, C3-10 alkenylene, C3-10 alkynylene, C3-20 cycloalkylene, C5-20 cycloalkenylene, C5-25 arylene, —COO—, —C(O)—, —S—, —CONR1—, —NR1—, —CH2CH2O—, —O—, or combination of two or more of the foregoing; C is independently C1-10 alkylene, C3-10 alkenylene, C3-10 alkynylene, C3-20 cycloalkylene, C5-20 cycloalkenylene, C5-25 arylene, —COO—, —C(O)—, —S—, —CONR1—, —NR1—, —CH2CH2O—, —O—, or combination of two or more of the foregoing; D is independently C1-10 alkylene, C3-10 alkenylene, C3-10 alkynylene, C3-20 cycloalkylene, C5-20 cycloalkenylene, C5-25 arylene, —COO—, —C(O)—, —S—, —CONR1—, —NR1—, —CH2CH2O—, —O—, or combination of two or more of the foregoing; a is 1; b is independently 0-10; c is independently 1-20; d is independently 0-20; p is greater than 0; R1 and R2 are independently hydrogen, C1-10 alkyl, C3-10 alkenyl, C3-10 alkynyl, C3-20 cycloalkyl, C5-20 cycloalkenyl, or C5-25 aryl; and wherein one or more of the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, and arylene may independently be branched, unbranched, unsubstituted, substituted, or contain at least one heteroatom.
地址 Richmond VA US