| 发明名称 |
Methods and compositions for cell-proliferation-related disorders |
| 摘要 |
Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2). |
| 申请公布号 |
US9434979(B2) |
申请公布日期 |
2016.09.06 |
| 申请号 |
US201213452136 |
申请日期 |
2012.04.20 |
| 申请人 |
Su Shin-San Michael;Dang Lenny;Gross Stefan;Jin Shengfang;Fantin Valeria |
发明人 |
Su Shin-San Michael;Dang Lenny;Gross Stefan;Jin Shengfang;Fantin Valeria |
| 分类号 |
A61K38/44;C12Q1/32;A61K31/225;C12Q1/68;A61K31/015;A61K31/05;A61K31/122;A61K31/355;A61K31/375;A61K31/381;A61K31/522;A61K31/7004;A61K31/713;A61K38/06 |
主分类号 |
A61K38/44 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of evaluating a 2-hydroxyglutaric aciduria human subject, the method comprising analyzing for the presence of a nucleic acid sequence corresponding to an isocitrate dehydrogenase (IDH) mutation having 2-hydroxyglutarate (2HG) neoactivity wherein the analysis comprises sequencing the nucleic acid sequence, thereby evaluating the 2-hydroxyglutaric aciduria human subject. |
| 地址 |
Newton MA US |
