发明名称 |
ENHANCING THE EFFECT OF CAR-ENGINEERED T CELLS BY MEANS OF NUCLEIC ACID VACCINATION |
摘要 |
The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to a method for stimulating, priming and/or expanding in vivo T cells genetically modified to express a chimeric antigen receptor (CAR) targeted to an antigen, comprising contacting the T cells with the antigen or a variant thereof in vivo. In one embodiment, the antigen or variant thereof is provided by administering a nucleic acid encoding the antigen or variant thereof. |
申请公布号 |
WO2016180778(A1) |
申请公布日期 |
2016.11.17 |
申请号 |
WO2016EP60332 |
申请日期 |
2016.05.09 |
申请人 |
BIONTECH CELL & GENE THERAPIES GMBH;TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH |
发明人 |
SAHIN, Ugur;REINHARD, Katharina;SIMON, Petra;MROZ, Karolina Anna;HOBOHM, Kathleen |
分类号 |
A61K39/00;A61K35/17;C07K14/725 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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