| 摘要 |
A compound of formula (I), or a pharmaceutically acceptable derivative thereof, wherein V represents -(CH2)d(O)e-, -CO-, or -CH(C1-6 alkyl)-; W is -O-, -S(O)a-, or -N(R<1>)- R<1 >represents H, C1-6 alkyl, (CH2)bCOR<2>, CO(CH2)bNR<2>R<3>, SO2R<2>, (CH2)cOR<2>, (CH2)cNR<2>R<3>, or (CH2)bhet<1>; het<1 >represents a saturated or unsaturated heterocycle of from 3 to 8 atoms containing one or more heteroatoms selected from O, N, or S, optionally substituted with C1-6 alkyl; X and Y independently represent H, C1-6 alkyl, halogen, OH, CF3, OCF3, OR<4>; Z represents -(CH2)f(O)g-, -CO- or -CH(C1-6 alkyl)-; Ring A represents a 4-7 membered, saturated N-containing heterocycle, optionally substituted with OH, and in which optionally at least one ring N is substituted with O; Ring B represents phenyl or a 4-7 membered unsaturated N-containing heterocycle, optionally substituted with OH, halogen, CN, CONH2, CF3, OCF3, and in which optionally at least one ring N is substituted with O; R<2 >and R<3 >independently represent H, C1-6 alkyl [optionally substituted with OH, halogen, N(C1-6 alkyl)2, or C1-6 alkyloxy], C1-6 alkyloxy, N(C1-6 alkyl)2, or [C3-8 cycloalkyl]; or R<2 >and R<3>, together with the nitrogen atom to which they are attached independently represent a heterocycle of from 3 to 8 atoms, optionally substituted with C1-6 alkyl; R<4 >represents straight or branched C1-6 alkyl, a
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