发明名称 |
CLONING AND EXPRESSION OF THE FULL LENGTH 110 KDA ANTIGEN OF ORIENTIA TSUTSUGAMUSHI TO BE USED AS A VACCINE COMPONENT AGAINST SCRUB TYPHUS |
摘要 |
The inventive subject matter relates to a recombinant 110 kDa protein from O. tsutsugamuchi, Karp, Kato and Gilliam strains and for a DNA expression system containing DNA encoding the 110 kDa protein of O. tsutsugamuchi. The invention also relates to the use of these recombinant contructs in a formulation for the induction of a protective immune response against O. tsutsugamuchi invection using. The inventive subject matter also relates to a recombinant 110 kDa O.tsutsugamuchi protein or 110 kDa fragments for the production of antigen for use in immunodiagnosistic asssays for scrub typhus.
|
申请公布号 |
WO2006078271(A3) |
申请公布日期 |
2006.12.21 |
申请号 |
WO2005US13255 |
申请日期 |
2005.04.19 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY |
发明人 |
CHING, WEI-MEI;CHAO, CHIEN-CHUNG |
分类号 |
A61K39/02;A61K39/00;C07H21/04;C12N15/00;G01N33/53;G01N33/534 |
主分类号 |
A61K39/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|