METHOD FOR PREPARING (2S,3R,4R)-3,5-DISUBSTITUTED-2-DEOXY-2-HYDROXY-2-METHYL-D-RIBOSE-Γ-LACTONE AND INTERMEDIATE THEREOF

摘要

The present invention relates to a method for preparing (2S,3R,4R)-3,5-disubstituted-2-deoxy-2-hydroxy-2-methyl-D-ribose-γ-lactone and an intermediate thereof. The intermediate has a structure represented by formula II. According to the present invention, a compound represented by formula II is used as an intermediate for preparing (2S,3R,4R)-3,5-disubstituted-2-deoxy-2-hydroxy-2-methyl-D-ribose-γ-lactone, so the stereoselectivity is good, the yield is high, the reaction condition is mild, and the raw material 2-C-methyl-D-ribonic acid-1,4-lactone for preparing the intermediate has wide sources, is simple to prepare and has low cost.