| 发明名称 | Shortened CD95-Fc variant fusion proteins, nucleic acids and host cells thereof | ||
| 摘要 | The present invention relates to an isolated fusion protein comprising an extracellular CD95 domain or a functional fragment thereof and an Fc domain or functional fragment thereof, formulations providing such fusion protein in a stable form as well as a method for producing such a fusion protein. | ||
| 申请公布号 | US9434783(B2) | 申请公布日期 | 2016.09.06 |
| 申请号 | US201314415871 | 申请日期 | 2013.07.18 |
| 申请人 | APOGENIX AG | 发明人 | Hill Oliver;Gieffers Christian;Thiemann Meinolf |
| 分类号 | C07K16/18;C07K14/705;C07K7/08;C07K16/00;C07K14/525 | 主分类号 | C07K16/18 |
| 代理机构 | Perkins Coie LLP | 代理人 | Perkins Coie LLP ;Kung Viola T. |
| 主权项 | 1. A fusion protein comprising (i) at least a functional fragment of an N-terminally truncated extracellular cluster of differentiation 95 (CD95) domain, wherein the functional fragment of the N-terminally truncated extracellular CD95 domain consists of the amino acid sequence of SEQ ID NO: 11 or 12, or a sequence having at least 97% identity to SEQ ID NO: 11 or 12, and (ii) at least an Fc domain or a functional fragment thereof, wherein the Fc domain is a human Fc domain consisting of the amino acid sequence of SEQ ID NO: 8 or a sequence having at least 97% identity to SEQ ID NO: 8. | ||
| 地址 | Heidelberg DE | ||