| 发明名称 |
LUTZOMYIA LONGIPALPIS POLYPEPTIDES AND METHODS OF USE |
| 摘要 |
Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishishmaniasis are disclosed. |
| 申请公布号 |
US2016279211(A1) |
申请公布日期 |
2016.09.29 |
| 申请号 |
US201615175329 |
申请日期 |
2016.06.07 |
| 申请人 |
The Government of the U.S.A. as represented by the Secretary of the Department of Health and Human S ;Fundaçao Oswaldo Cruz (FIOCRUZ) |
发明人 |
Valenzuela Jesus G.;Ribeiro Jose M.C.;Barral Aldina;Netto Manoel Barral;Brodskyn Claudia I.;Gomes Regis |
| 分类号 |
A61K39/008;A61K39/00;C07K14/435 |
主分类号 |
A61K39/008 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An expression vector comprising:
a nucleic acid sequence encoding a salivary Lu. longipalpis polypeptide, wherein the polypeptide comprises amino acid residues 23-115 of SEQ ID NO: 55; and a heterologous expression control sequence. |
| 地址 |
Rockville MD US |
