PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HEART DISEASES

摘要

The present invention is related to a pharmaceutical composition comprising cells committed to the generation of heart tissue and at least one pharmaceutically acceptable excipient produced according to internationally recognized standards for pharmaceutical product manufacture, a process for the manufacture of such a pharmaceutical composition and a kit for the administration of said pharmaceutical composition which comprises a container containing said pharmaceutical composition.

主权项

1. A pharmaceutical composition comprising intermediate phenotype cells committed to the generation of heart tissue, wherein said cells show:
i) an observed increase in expression level of both MEF2C and at least one further gene selected from the group consisting of:
Nkx2.5, Tbx5, GATA4, GATA6, Mesp1, FOG1 FOG2, Flk1 and homologues thereof; as compared to a non-cardiopoietic reference; and ii) an absence of detectable levels of MYH7 expression; and at least one pharmaceutically acceptable excipient, wherein said at least one pharmaceutically acceptable excipient is a preservation solution; wherein the contents of total non-cardiopoietic cells is between 0% and 50% of the total number of cells.