COMPOSITIONS COMPRISING SPICAMYCIN DERIVATIVES AND METHODS OF USE THEREOF

摘要

The present invention relates to compositions comprising spicamycin derivatives, methods of making such compositions, and their use in the treatment and/or prevention of pain, including neuropathic pain.

主权项

1. A composition comprising:
a) a spicamycin derivative of Formula II:wherein R1 and R2 are different from each other and represent H or OH, and R represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, or cycloalkyl;
b) a biocompatible alcohol that solubilizes said spicamycin derivative; c) glycerin or a glycol that is miscible with said biocompatible alcohol and solubilizes said spicamycin derivative; and d) a surfactant soluble in a mixture of said biocompatible alcohol and said glycerin or glycol;wherein said composition is substantially free of particulates, and is substantially free of mono-ethanolamine and N,N-dimethyl acetamide (DMAC), and wherein said composition is a single-phase solution.