RECOMBINANT AAV BASED VACCINE METHODS

摘要

The present invention relates to recombinant adeno-associated virus (rAAV) based materials and methods for eliciting an immune response to a pathogen. The present invention provides vector sets comprising a priming vector and a boosting vector, wherein at least one of the vectors in the vector set is a rAAV vector, and methods for eliciting a prophylactic immune response in a mammalian subject susceptible to infection by a pathogen, such as for example, an RNA virus, including HIV-1, and methods for eliciting a therapeutic immune response in a mammalian subject infected by a pathogen that has progressed to a disease state associated with the pathogen, such as for example, an RNA virus, including HIV-1. In particular, the present invention provides methods for eliciting an enhanced boost immune response in a mammalian subject susceptible to infection by or infected by a pathogen.