| 摘要 |
The present invention provides compounds of formula (I): where X is R1-(CR3R4)nOC(O)-; R1-(CR3R4)nC(O)-; R1-C(O)NH(CR3R4)nOC(O)-; R1-C(O)NH(CR3R4)nC(O)-; R1-C(O)(CR3R4)nOC(O)-; or R1-C(O)(CR3R4)nC(O)-; where R1 is optionally substituted C5-10 aryl or heteroaryl; OH or NH2; where R3 and R4 are independently H or methyl; and n is 0 to 6; and Y is -CF3 or one of: where R2 is C1-8 alkyl optionally substituted with halo or -OH; -(CR6R7)p-C5-6 aryl optionally substituted with halo, -OH, C1-8 alkyl, C1-8 haloalkyl, -(CH2)mC(O)NH2 or -(CH2)mOCH3; where R6 and R7 are independently H or methyl; m is 0 to 4, and p is 0 or 1 or a pharmaceutically acceptable salt, ester, metabolite or prodrug thereof
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