发明名称 OLIGOMER-CONTAINING BENZAMIDE-BASED COMPOUNDS
摘要 The invention relates to (among other things) oligomer-containing benzamide-based compound compounds. A compound of the invention exhibits one or more advantages over corresponding compounds lacking the oligomer.
申请公布号 US2016339108(A1) 申请公布日期 2016.11.24
申请号 US201615164607 申请日期 2016.05.25
申请人 Nektar Therapeutics 发明人 Cheng Lin;Riggs-Sauthier Jennifer;Anand Neel K.
分类号 A61K47/48;A61K31/166;C07C237/44 主分类号 A61K47/48
代理机构 代理人
主权项 1. A compound comprising a residue of a benzamide-based compound covalently attached via a stable or releasable linkage to a water-soluble, non-peptidic oligomer; wherein the residue of the benzamide-based compound is a residue of a compound of Formula I: wherein: R1 is lower alkyl;R2 is lower alkyl;a is 1, 2, 3, or 4;Y is O or S;R3 is lower alkyl;R4 is hydrogen, halo, lower alkoxy, amino, or lower alkylamino;R5 is hydrogen, halo, lower alkoxy, amino, or lower alkylamino; andR6 is hydrogen, halo, lower alkoxy, amino, or lower alkylamino; and pharmaceutically acceptable salts thereof.
地址 San Francisco CA US