发明名称 |
Multifunctional biomaterials as scaffolds for electronic, optical, magnetic, semiconducting, and biotechnological applications |
摘要 |
One-dimensional ring structures form M13 viruses were constructed by two genetic modifications encoding binding peptides and synthesis of a heterobifunctional linker molecule. The bifunctional viruses displayed an anti-streptavidin peptide and hexahistidine (SEO ID NO: 4) peptide at opposite ends of the virus as pIII and pIX fusions. Stoichiometic addition of the streptavidin-NiNTA linker molecule led to the reversible formation of virus-based nanorings with circumferences corresponding to lengths of the packagable DNAs. These virus-based ring structures can be further engineered to nucleate inorganic materials and form metallic, magnetic, or semiconductor nanorings using trifunctionalized viruses.
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申请公布号 |
US2005170336(A1) |
申请公布日期 |
2005.08.04 |
申请号 |
US20040965227 |
申请日期 |
2004.10.15 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
BELCHER ANGELA M.;PEELLE BEAU R.;NAM KI T. |
分类号 |
C07K;C12N7/00;C12N15/86;C12Q1/70;H01L51/00;(IPC1-7):C12Q1/70 |
主分类号 |
C07K |
代理机构 |
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代理人 |
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地址 |
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