| 摘要 |
This invention relates to novel associations between polymorphisms in the genes encoding the human Epithelial Na+ Channel (ENaC) and COPD. More particularly, the invention relates to a method for assessing the predisposition and/or susceptibility of an individual to COPD, which method comprises detecting the presence of a polymorphism in one or more human ENaC-encoding genes, in particular position 3870 of SEQ ID:1 encoding SCNN1B or position 10544 of SEQ ID NO: 2 encoding SCNN1G. The invention also relates to a method of treating a human identified as having a polymorphism in one or more human ENaC-encoding genes with a drug capable of treating COPD. |
