Stents having controlled elution

摘要

Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

主权项

1. A device comprising
a. a stent; and b. a coating on the stent comprising five layers: a first layer comprising at least one bioabsorbable polymer; a second layer comprising at least one active agent; a third layer comprising at least one bioabsorbable polymer; a fourth layer comprising at least one active agent; and an outer layer comprising at least one bioabsorbable polymer; wherein each of said bioabsorbable polymer layers comprises a separately sintered bioabsorbable polymer layer; wherein said outer layer comprising said at least one bioabsorbable polymer is sufficiently thin so that the active agent is present in crystalline form on at least one region of an outer surface of the coating opposite the stent and wherein 50% or less of the total amount of active agent in the coating is released after 24 hours in vitro elution; wherein the active agent comprises a macrolide immunosuppressive (limus) drug.