Adeno-associated virus virions with variant capsid and methods of use thereof
摘要
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
申请公布号
AU2012245328(B2)
申请公布日期
2016.09.29
申请号
AU20120245328
申请日期
2012.04.20
申请人
The Regents of the University of California
发明人
Schaffer, David V.;Klimczak, Ryan R.;Koerber, James T.;Flannery, John G.;Dalkara Mourot, Deniz;Visel, Meike;Byrne, Leah C.T.