| 发明名称 | Synthesis of Raltegravir | ||
| 摘要 | The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2-methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V). | ||
| 申请公布号 | US9475799(B1) | 申请公布日期 | 2016.10.25 |
| 申请号 | US201615195477 | 申请日期 | 2016.06.28 |
| 申请人 | Emcure Pharmaceuticals Limited | 发明人 | Gurjar Mukund Keshav;Sonawane Swapnil Panditrao;Maikap Golakchandra Sudarshan;Patil Gulabrao Dagadu;Shinde Shivnath Bhaupatil;Shalikrao Pankaj;Mehta Samit Satish |
| 分类号 | C07D271/10;C07D413/12 | 主分类号 | C07D271/10 |
| 代理机构 | Florek & Endres PLLC | 代理人 | Florek & Endres PLLC |
| 主权项 | 1. A compound of formula: wherein R is CN; wherein R′ is H or CH3; wherein R2 is H and R3 is C1-4 alkyl group; or | ||
| 地址 | IN | ||